mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation
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چکیده
منابع مشابه
mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway
The mechanistic target of rapamycin (mTOR) integrates both intracellular and extracellular signals to regulate cell growth and metabolism. However, the role of mTOR signaling in osteoblast differentiation and bone formation is undefined, and the underlying mechanisms have not been elucidated. Here, we report that activation of mTOR complex 1 (mTORC1) is required for preosteoblast proliferation;...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2017
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.00668-16